What is the relationship of serum to plasma

Difference between Serum and Plasma

what is the relationship of serum to plasma

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J Clin Endocrinol Meta. Plasma concentrations of soluble TNF-alpha receptors in obese subjects. An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women. Lipoprotein oxidation and plasma vitamin E in nondiabetic normotensive obese patients. Adherence to the Mediterranean diet is associated with lower abdominal adiposity in European men and women.

what is the relationship of serum to plasma

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Changes in both global diet quality and physical activity level synergistically reduce visceral adiposity in men with features of metabolic syndrome. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. A clinical view of the obesity problem. Regulation of energy intake: Present Knowledge in Nutrition. Psychiatric disorders in a rural community in West Bengal: Fluoxetine versus sertraline and paroxetine in major depressive disorder: Silverstone PH, Ravindran A.

Based on results of this study, most ischemic stroke patients with mild to moderate severity at admission time had normal serum uric acid levels, while a review of the reports of other studies in this regard has controversial results.

On the contrary, a report by Chiquete in indicated that a low concentration of serum uric acid was associated with good short-term outcomes in patients with stroke [ 21 ].

These contradictions also exist on the relationship of high serum uric acid levels and the severity of stroke. Results of 2 studies by Amaro in and showed that increased serum uric acid levels were associated with better outcomes for stroke patients [ 2223 ].

Wu and colleagues also reported that uric acid could be a neuroprotective agent for acute ischemic stroke [ 19 ]. In their report, Wang et al. On the other hand, contrary to the findings suggesting a positive effect of serum uric acid level in the short-term prognosis of stroke, a study by Storhaug in [ 25 ] and some other studies [ 13 ] demonstrated that increased levels of uric acid could be a risk factor for ischemic stroke.

Our study suggested there was no significant relationship between the serum uric acid levels and the gender of stroke patients. This issue has been a topic of debate among researchers.

Difference between Serum and Plasma

A case-control study by Jimenez et al. They reported that serum levels of uric acid alone were not related to ischemic stroke [ 26 ], a finding similar to ours.

In another study to evaluate the relationship between SUA and ischemic stroke according to gender, it has been concluded that, in women with ischemic stroke who are treated with Alteplase, prescribing uric acid reduces the extent of the lesion and results are better than placebo [ 28 ]. The reason behind not finding a relationship between serum uric acid levels and gender of our stroke patients was not actually clear. Although the number of our studied patients was small, based on this study results, we could conclude that mechanism of possible effects of uric acid on stroke might be the same in both genders.

We observed higher levels of serum uric acid in our diabetic embolic ischemic stroke patients, compared with thrombotic cases. There is a lot of research on the relationship between serum uric acid levels and diabetes.

In a case-control study, the mean SUA level in hypertensive and diabetic subjects was higher than that in normotensive and nondiabetic patients [ 29 ], which is generally in line with our findings.


Although SUA level in the prognosis of our diabetic ischemic patients had not any effect, Shuolin Wu showed that low SUA levels could predict the short-term poor functional outcome in acute stroke cases with normoglycaemia compared with diabetic or prediabetic cases [ 30 ]. While our study showed a difference between serum uric acid levels in ischemic thrombotic and embolic stroke only in diabetic patients, a report by Yang et al. Although embolic ischemic patients of our study included both of artery-to-artery embolisms and the cardioembolisms, it seems that according to the findings of these two studies and some other studies, there is a relationship between serum SUA level and acute artery-to-artery or cardioembolic ischemic stroke in diabetics, which should be further investigated to confirm this relationship and its exact type.

In our study, ischemic stroke patients with low serum levels of magnesium had significantly lower amounts of serum uric acid compared with those having normal or high serum levels of magnesium.

The cause or causes of this finding and its significance are not clear to us at this time.

what is the relationship of serum to plasma

However, the relationship between magnesium and stroke has been extensively studied. In a study by Adebamovo et al.

Relationship between plasma vitamin C and serum diagnostic biochemical markers in lactating cows.

To confirm the clinical value of the our results about possible correlation between serum levels of magnesium and uric acid in stroke, more studies should be conducted with higher sample sizes. There are studies on the relationship between uric acid and vitamin D in general, such as the one by Peng et al. Our findings, however, indicate no significant relationship between uric acid and vitamin D and calcium in stroke.

It is also worth noting that our study showed no meaningful relationship between serum uric acid levels and stroke risk factors such as hypertension, ischemic heart disease, hyperlipidemia, and smoking. In addition, we did not find a significant link between serum uric acid levels and some other associated factors such as type of the place of residence rural-urbanwhich might had different SUA levels depending on the different lifestyle and diet in the two communities.