Como antiarrítmico: • Dosis inicial de carga: 1,25 mg/kg i.v en infusión intermitente, cada 5 min. hasta un total de 15mg/kg. • Mantenimiento. calculo de dosis factor goteo regla de tres. CONECTAR A EQUIPO MACRO IV DIRECTA FENITOINA (EPAMIN) ANTICONVULSIVANTE. DIFENILHIDANTOINA (Fenitoina) Mecanismo de Acción: . en el hígado y el 35 % de una dosis oral aparece en la orina, vida media 4 h.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Interrelations of mortality and malformations in rats. Cerebellar difenilhidantoins following acute intoxication with phenytoin. Se realiza una revision actualizada y completa de la bibliografia y se citan los autores mas pertinentes.

Frode Fonnum 61 Estimated H-index: Control animals received saline at same conditions. Harald Masur 8 Estimated H-index: Effect of prenatal phenytoin administration on postnatal development of the rat: Rapport 3 Estimated H-index: Diphenylhydantoin DFH is known to yield cerebellar ataxia in chronically treated epileptic patient due to cerebellar atrophy with loss of Purkinje cells.


Decreased epithelium thickness and papilla absence in the treated group can be observed. Difenilhidantoinw view content sources and attributions, please refer to our editorial policy.

It is not difeenilhidantoina as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. Folate antagonism following teratogenic exposure to diphenylhydantoin.

The exact mechanism in which the phenytoin acts in the lingual mucosa of rat fetus is not yet known. Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity. However, phenytoin acts in the stratified squamous epithelium along the several areas of the rat fetus’ body in a very similar way, and turns into slender epithelium, with smaller size cells and nucleus and greater number of cells by mm 3as observed in the mouth flooring Gonzaga et al.

Due to the refractory characteristics of his seizures he was put on DFH mg daily, and developed a pancerebellar syndrome.

Afterwards, the heads were dehydrated, diaphanized, included in paraffin, which was then sectioned in slices 6 micrometers thickthen colored in hematoxylin and eosin. The karyometric parameters for the lingual mucosa were: Med J Aust1: Dam 70 Estimated H-index: Neurological sequelae following Dilantin overdose in a patient and in experimental animals.

Karyometric parameters average values of the epithelium thorny layer cells nucleus from anterior dorsal, posterior dorsal and ventral regions of tongue of control C and treated T fetuses.


Resaltar la importancia y posibilidad de efectuar un diagnostico precoz. Teratogenic potential of almokalant, dofetilide, and d-sotalol: Literature review and case presentation.


Available for Android and iOS devices. Kaeko Kitamura 1 Estimated H-index: In the doss dorsal region of the tongue, the epithelium showed to be less thick, with no papilla; the cells from the prickle-cell and basal layer showed to be more rounded and morphologically very alike, and their nuclei showed loose chromatin, evident nucleolus, and two-nucleolus nuclei were often observed.

TC and MRI did not show cerebellar atrophy. Histological aspect of the epithelium of tongue’s ventral region of control group a and treated group b. Such facts point to more immature fetuses.

Weight loss in rats was also observed by Mullenix et al. Consult with your healthcare professional before difeniphidantoina any medication. Histometric data provided quantitative results confirming the histological findings Tables I and II. After one year of follow up his neurological picture did not change, while he was seizures free.