Comunicado de la FDA sobre la seguridad de los medicamentos: Nuevo factor de riesgo para la leucoencefalopatía multifocal progresiva. Abstract. PASQUALOTTO, Alessandro Comarú; MATTOS, Alice J.Z. de and ROCHA, Marineide Melo. Leucoencefalopatia multifocal progressiva confirmada por. A leucoencefalopatia multifocal progressiva (LMP) é uma doença desmielinizante do sistema nervoso central (SNC) causada pela reativação do vírus JC (JCV).

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It is commonly multifocal and has an asymmetric pattern of demyelinationuni- or bilaterally, without mass effect, and invariably without contrast enhancement. Clinically, the development of PML in multiple sclerosis patients poses an additional difficulty in the diagnosis, since PML onset is frequently mistaken with MS exacerbation, stroke or other neurological condition Support Center Support Center.

Once reactivated in the CNS, the virus infects and destroys oligodendrocytes, which are responsible for the formation and maintenance of myelin sheaths. The introduction of more potent antiretroviral regimens led to a considerable decrease in its incidence and mortality in the last 17 years. PML occurs almost exclusively in patients with severe immune deficiencymost commonly among patients with acquired immune deficiency syndrome AIDSbut people on chronic immunosuppressive medications including chemotherapy are also at increased risk of PML, such as patients with transplants, Hodgkin’s lymphomamultiple sclerosispsoriasisand other autoimmune diseases.

To quiz yourself on this article, log in to see multiple choice questions. PML lesions are more often multifocal and asymmetric, with greater predilection for the subcortical white matter and are associated with more pronounced signal change on T1-weighted images, while in HIV-associated demyelination, lesions are often isointense on T1, and may not be visible.


Since restoration of the cellular immune response against JCV is the best predictor of survival in PML 8the introduction of combined antiretroviral drugs led to a significant improvement in mortality. Brain herniation Reye’s Hepatic encephalopathy Toxic encephalopathy Hashimoto’s encephalopathy.

There may be involvement of deep gray structures, by affection of myelin fibers that pass through basal ganglia. Read it at Google Books – Find it at Amazon. This page was last edited on 29 December prohressiva, at Since diagnosis, he had remained asymptomatic and in clinical follow-up, under no specific therapy.

Progressive multifocal leukoencephalopathy in non-HIV patient

HIV encephalitis lesions are commonly periventricular, diffuse, symmetric, and tend to spare subcortical U-fibers. This is an open-access article distributed under the terms of the Creative Commons Attribution License. Risk of natalizumab-associated progressive multifocal leukoencephalopathy. From Wikipedia, the free encyclopedia.

Brain disorders Mental disorders due to a general medical condition Viral infections of the central nervous system Rare diseases Slow virus diseases Rare infectious diseases.

Progressive multifocal leukoencephalopathy

Case 8 Case 8. Clinically, HIV-associated demyelination presents as global cognitive disorder and dementia, while in PML motor, sensory or cognitive focal deficits predominate. leucofncefalopatia

Unsourced material may be challenged and removed. Primary infection occurs in childhood and it is asymptomatic in most patients.

Braz J Iinfect Dis ; It is considered the most common clinical manifestation of John Cunningham virus JC virus infection in the brain 7and is seen in three clinical contexts:. There is a predilection for the parieto-occipital lobes. J Am Leucoencefa,opatia Dermatol ; Clinical outcome of long-term survivors of progressive multifocal leukoencephalopathy. From the to ‘s, PML was observed mostly in patients being treated with corticosteroids and other immunosuppressive drugs, as well as individuals ;rogressiva hematological malignancies.


The virus remains latent mainly in the kidneys and lymphoid organs and is reactivated and spreads to the brain, almost exclusively in the setting of advanced immunosuppression.

T2-weighted image reveals asymmetrical areas of hyperintensity, more marked in the left temporal region white arrows. However, basal ganglia, brainstem and cerebellum also can be involved. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant recipients. It typically spares the optic nerve and the spinal cord. Rarely, JCV has been associated with meningitis and encephalitis 28 One-third to one-half of people with PML die in the first few months following diagnosis, depending on the severity of their underlying disease.

Most often, PML presents with motor deficits, visual disturbances and cognitive impairment, in a subacute evolution. Mirtazapine use in human immunodeficiency virus-infected patients with progressive multifocal leukoencephalopathy. It is caused by the reactivation of the JC virus genus: Infusion of donor T cells specific to the related BK polyomavirus has shown possible effect in treating PML in one small study by Katy Rezvani’s group, but needs further study.