Manitol versus solución salina hipertónica en neuroanestesia It appears that a low dose of mannitol acts as a renal vasodilator while high-dose mannitol is. Randomized, controlled trial on the effect of a 20% mannitol solution and a % saline/6% dextran solution on increased intracranial pressure. Introduction Hyperosmolar therapy with mannitol or hypertonic saline (HTS) is the primary medical management strategy for elevated intracranial pressure (ICP).

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Comparison between hypertonic saline and mannitol in the reduction of elevated intracranial pressure in a rodent model of acute cerebral injury. Hypertonic saline reduces cumulative and daily intracranial pressure burdens after severe traumatic brain injury. Chen, University of California, San Diego. Other problems include ARF, arrhythmias, haemolysis, acute lung oedema and pontine myelinolysis.

Mannitol or hypertonic saline in the setting of traumatic brain injury: What have we learned?

Hypertonic saline for treating raised intracranial pressure: Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: HTS can cause a rapid increase in serum sodium concentrations, raising concern for central pontine myelinolysis. From tothe Revista Brasileira de Anestesiologia was published every three months.

Methodology for the control of intracranial pressure with hypertonic mannitol. The most common problem associated with the use of HTS, ve in the form of repeated doses or in continuous infusion, is hyperchloremic acidosis.

It acts on ICP min after administration, optimizing the rheological properties of blood by reducing its viscosity, lowering the haematocrit, and increasing CBF and O2 supply. Lazaridis, in a meta-analysis conducted inidentified 11 papers on the use of Physiologically, HTS has many theoretical advantages over mannitol.

J Neurosurg Anesthesiol, 9pp. We conducted this research in order to assess the benefits and side effects of osmotherapy and to identify the current trends in the manitl of IH and cerebral oedema.



The critical importance of ICP in the management of traumatic head injuries and nontraumatic neurologic diseases e. Intraocular and intracranial pressure: Conflicts of interest There are no conflicts of interest.

The most commonly utilized hyperosmolar agents are mannitol and HTS. Print Send to a friend Export reference Mendeley Statistics. The following medical subject headings were used: Safety of hypertonic hyperoncotic solutions-a survey from Austria.

The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemorrhagic shock: The effects of mannitol on blood viscosity. Both mannitol and HTS have proven to be effective at controlling ICP, through different mechanisms; osmotic dehydration of the cerebral interstitium; reduction of blood viscosity; increased red blood cell deformation; and hiertonica microcirculation.

All of these advantages suggest that HTS should be studied extensively so it can possibly be used instead of mannitol as first line therapy for the management of high ICP in patients with TBI. Both therapies have similar mechanisms of action in the brain, using an osmotic gradient — induced shift of extravascular to intravascular water across the blood — brain barrier.

Out of the sklucion patients who were randomized in each group, 9 patients received only mannitol, 12 received only sodium lactate, and 13 patients crossed over and received both mannitol and sodium lactate. Hypertonic saline worsens infarct volume after transient focal ischemia in rats.

The benefit of HTS relative to long-term neurological out-comes compared to that of mannitol is yet unclear. Mannitol for acute traumatic brain injury.

Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. Human glial cell production of lipoxygenase-generated eicosanoids: Intracranial hypertension occurs during the acute phase of ICH and it is a predictor of poor prognosis in these patients. Nipertonica randomized clinical trail.


An elevated osmolar gap correlates with mannitol accumulation, and a low level ensures mannitol clearance.

Hyperosmolar therapy with mannitol or hypertonic saline solution is the main medical strategy for the clinical management of intracranial hypertension IH and cerebral oedema. Ultimately, judgment and careful dissection of individual clinical scenario manotol the context of a rigorous interpretation of the existing literature will be needed to best serve the needs of our patient.

HTS treatment was associated with an increase in PbtO 2 from baseline Metabolic acidosis in the critically ill: Wise BL, Chater N. It has a low probability of anaphylactic reactions or of transmitting infectious agents, and it gipertonica controlled by serum Na levels.

For example, maniotl response to increased brain volume e. However, the comparative effects of these two agents on cerebral physiology, rather than ICP alone, should be evaluated.

Frequently, neurosurgical patients have sodium imbalances. Cerebral blood flow augmentation in patients with severe subarachnoid haemorrhage. After reviewing potential articles, the reviewers were unable to find any Solucioh that met their inclusion criteria. Effects of single, repeated and massive mannitol infusion in the dog: Cerebral blood flow drops globally after SAH and this is manifested in worsening of the neurological status.

Hypertonic saline as a safe and efficacious treatment of intracranial hypertension.